MEDICATIONS

Mood stabilizers (including lithium)

The core of long-term bipolar treatment, chosen and monitored by a psychiatrist.

How it works

Lithium and certain anticonvulsant and antipsychotic medicines help prevent and treat mood episodes. Lithium requires regular blood tests.

What the evidence says, use by use

Evidence is specific to the condition, population and—for devices—the exact product. One label never covers everything.

Bipolar Disorder: Treating and preventing mood episodes

Established
Who was studied / who it’s for: Adults with bipolar disorderWhat this label means: Strong research and/or authoritative clinical guidelines support this specific use.

Bipolar guidelines recommend lithium as the first-line long-term treatment, with other mood stabilizers or antipsychotics as alternatives.

Sources: NICE (UK) · NIMH

Who usually provides it

Psychiatrists.

Cautions & things to know

  • Lithium levels must be monitored; dehydration and some common medicines (like certain pain relievers) can raise levels.
  • Several mood stabilizers carry pregnancy risks—discuss family planning.

Questions for a clinician

Conversation prompts, not a treatment plan.

  • How often do we need blood tests?
  • What are early warning signs of a mood episode we should plan for?

Educational, not medical advice. NeuroCoach is an educational and care-navigation resource, not a medical provider. Information about medications, supplements, therapies, devices, clinical trials and community experiences is provided for education and exploration and is not a recommendation, diagnosis or treatment plan. Evidence varies substantially among interventions. Decisions about medical or mental-health treatment should be made with an appropriately qualified healthcare professional. Do not start, stop or change medication, supplements or treatment based solely on information found here.

Sources

Sources checked October 5, 2026. Links support this page; they don’t imply endorsement of NeuroCoach.

  1. Bipolar disorder: assessment and management (CG185) NICE (UK)
  2. Bipolar Disorder NIMH